Israeli soldiers shot dead seven Palestinians , including two boys, who were among thousands of people protesting at the fortified Gaza Strip border.
Israel's military said its troops resorted to live fire, and an air strike, after rocks were thrown at them.
Gaza health officials said 290 people had been wounded, 90 of them by gunshots.
They identified the dead as males, two of them aged 12 and 14.
The protests have been taking place weekly at the border for the last six months.
At least 190 Palestinians have been killed since the Gaza protests began on March 30 to demand rights to lands lost to Israel in the 1948 war.