Muhammad Aamir and all-rounder Faheem Ashraf took one wicket each.
The team had struck early with pacer Mohammad Abbas picking up the wicket of Mark Stoneman.
Hasan Ali picked up the second wicket of the innings when he dismissed Joe Root. The third wicket also fell to Hasan Ali when David Malan was caught behind for six runs.
Faheem Ashraf removed Jonny Bairstow for 27, and just as Alastair Cook looked settled Mohammad Amir bowled him for 70.
Cook, in his 153rd consecutive Test, which equalled Australia great Allan Border´s all-time record for successive appearances at this level, revived England with a fine 70.
But shortly before tea he was bowled by Amir, a team-mate when Essex won the County Championship last season, as the left-arm quick produced a brilliant delivery that cut away late off the pitch late to clip the top of the opener´s off stump.
Cook faced 148 balls, including 14 fours
Ben Stokes was unbeaten on 36, having hoisted leg-spinner Shadab Khan for the first six of this match. Jos Buttler, recalled as a specialist number seven, was unbeaten on 13.
Root opted to bat first in the opening match of this two-Test series, despite the overcast conditions and a green-tinged pitch offering the promise of assistance for Pakistan´s pacemen.
Both England and Pakistan´s have concerns over their batting so it was a particularly bold decision by Root.
It certainly looked a good toss for Pakistan to lose as three members of an England top-order that repeatedly failed during winless winter Test tours of Australia and New Zealand all fell for single-figure scores. - APP/AFP