According to the local security officials, the airstrike was carried out late on Wednesday night in the outskirts of Tarinkot city, the provincial capital of Uruzgan.
A security source involved in the operations said a local Taliban commander identified as Mullah Basir was also among those killed.
The source further added that two Taliban insurgents were also wounded in the airstrike.
The anti-government armed militant groups including the Taliban insurgents have not commented regarding the report so far.
This comes as a local leader of the Taliban group was killed in a similar airstrike conducted by the US forces in Tarinkot city last Wednesday.
A local police official confirmed last week that that six Taliban insurgents including one of their local leaders Mullah Ghazi were killed and four others were wounded.
The source further added that a hideout of the Taliban group was eliminated in the airstrike in Garam Aab area.
Several weapons, ammunition, and explosives belonging to the Taliban group were destroyed in the airstrike, the police official added.