He was born on June 13, 1899 in Peshawar. He entered politics in 1928 and joined Indian National Congress but soon developed differences with the party.
He joined All-India Muslim League in 1932 and became a confidante of Pakistan s founder Muhammad Ali Jinnah. Sardar Abdur Rab Nishtar died on 14 February 1958 in Karachi.
He was buried at Mazar-e-Quaid near the Tomb of Muhammad Ali Jinnah, the founding father of Pakistan to acknowledge his services in the cause of Pakistan.