Trump departs for Florida to meet Chinese President
Air Force One departed from Joint Base Andrews in rainy weather shortly after 12:30 pm (1630 GMT).
Few details have been released on the leaders' agenda apart from plans for Trump and Xi to dine Thursday night at the president's Mar-a-Lago estate with their respective wives Melania Trump and Peng Liyuan before holding a series of meetings on Friday.
The Republican president, whose stance on China has been in flux, will be closely watched for signals as to the direction of US relations with the rising Asian giant under his administration.
"It's going to be very interesting. Nobody really knows," Trump said on Fox News before his departure.
Reaffirming his dim view of US-Chinese trade relations, Trump insisted the United States has "not been treated fairly on trade for many, many years."
"No president has taken care of this the way they should have," he added.